Assay Detail

CHEMBL934873

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Binding

Inhibition of Staphylococcus aureus FabH by direct binding assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Staphylococcus aureus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Wang J, Kodali S, Lee SH, Galgoci A, Painter R, Dorso K, Racine F, Motyl M, Hernandez L, Tinney E, Colletti SL, Herath K, Cummings R, Salazar O, González I, Basilio A, Vicente F, Genilloud O, Pelaez F, Jayasuriya H, Young K, Cully DF, Singh SB.
Proc Natl Acad Sci U S A (2007) 104 : 7612 -7616
PubMed 17456595 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	4.48	4.79

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1092943	PLATENCIN	—	1	4.79
CHEMBL560671	PLATENSIMYCIN	—	1	4.17

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1092943	PLATENCIN	IC50	=	16200.0	nM	4.79
CHEMBL560671	PLATENSIMYCIN	IC50	=	67000.0	nM	4.17