Assay Detail
Binding
CHEMBL935136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]oCRF from rat CRF1 after 2 hrs by Betaplate scintillation counter
17
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL4649) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.89 | 8.43 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271197 | — | — | 2 | 8.43 |
| CHEMBL270948 | — | — | 2 | 8.29 |
| CHEMBL405198 | — | — | 2 | 8.25 |
| CHEMBL273040 | — | — | 2 | 8.19 |
| CHEMBL270738 | — | — | 2 | 8.17 |
| CHEMBL269833 | — | — | 2 | 8.14 |
| CHEMBL271370 | — | — | 2 | 7.51 |
| CHEMBL271368 | — | — | 2 | 6.13 |
| CHEMBL272617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271197 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL271197 | — | IC50 | = | 3.715 | nM | 8.43 |
| CHEMBL270948 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL270948 | — | IC50 | = | 5.129 | nM | 8.29 |
| CHEMBL405198 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL405198 | — | IC50 | = | 5.623 | nM | 8.25 |
| CHEMBL273040 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL273040 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL270738 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL270738 | — | IC50 | = | 6.761 | nM | 8.17 |
| CHEMBL269833 | — | IC50 | = | 7.244 | nM | 8.14 |
| CHEMBL269833 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL271370 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL271370 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL271368 | — | IC50 | = | 741.31 | nM | 6.13 |
| CHEMBL271368 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL272617 | — | Activity | - | — | - |