Assay Detail
Binding
CHEMBL935156
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+)-[5-methyl-3H]PN200-100 from L type calcium channel in guinea pig heart ventricles
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Imidazo[2,1-b]thiazole system: a scaffold endowing dihydropyridines with selective cardiodepressant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.87 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.83 |
| CHEMBL409148 | — | — | 1 | 6.80 |
| CHEMBL271355 | — | — | 1 | 6.51 |
| CHEMBL272472 | — | — | 1 | 5.35 |
| CHEMBL439315 | — | — | 1 | - |
| CHEMBL271964 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | Ki | = | 1.479 | nM | 8.83 |
| CHEMBL409148 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL271355 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL272472 | — | Ki | = | 4466.84 | nM | 5.35 |
| CHEMBL439315 | — | Ki | < | 10000.0 | nM | - |
| CHEMBL271964 | — | Ki | < | 10000.0 | nM | - |