Assay Detail
Binding
CHEMBL935183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human MR ligand binding domain expressed in african green monkey COS7 cells in presence of aldosterone by Gal4 hybrid assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.62 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267431 | ASOPRISNIL | 3.0 | 1 | 5.80 |
| CHEMBL407848 | — | — | 1 | 5.43 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267431 | ASOPRISNIL | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL407848 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | - | — | - |