Assay Detail
Functional
CHEMBL935318
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Cytotoxicity against human HepG2 cells assessed as inhibition of [3H]thymidine after 48 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.76 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | 3.0 | 1 | 8.27 |
| CHEMBL406496 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273862 | HYDROXYCAMPTOTHECIN | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL406496 | — | IC50 | = | 56.5 | nM | 7.25 |