Assay Detail
Binding
CHEMBL935410
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Inhibition of purified human recombinant IDO
42
Total Activities
37
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.11 | 7.26 |
| Activity | 5 | - | - |
| Ki | 1 | 6.92 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407954 | — | — | 2 | 7.26 |
| CHEMBL260961 | — | — | 1 | 7.09 |
| CHEMBL270735 | — | — | 1 | 6.92 |
| CHEMBL272032 | — | — | 1 | 6.92 |
| CHEMBL261179 | — | — | 1 | 6.89 |
| CHEMBL261178 | — | — | 2 | 6.73 |
| CHEMBL556930 | — | — | 1 | 6.72 |
| CHEMBL272253 | DEHYDRO-ALPHA-LAPACHONE | — | 1 | 6.67 |
| CHEMBL260744 | — | — | 1 | 6.61 |
| CHEMBL318782 | Dichlon | — | 1 | 6.55 |
| CHEMBL412131 | — | — | 1 | 6.47 |
| CHEMBL271827 | — | — | 2 | 6.44 |
| CHEMBL272225 | — | — | 1 | 6.29 |
| CHEMBL106562 | 2-Methoxy-1,4-naphthoquinone | — | 1 | 6.14 |
| CHEMBL411532 | — | — | 1 | 6.06 |
| CHEMBL260523 | — | — | 1 | 6.03 |
| CHEMBL443067 | — | — | 2 | 6.01 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 6.00 |
| CHEMBL43612 | JUGLONE | — | 1 | 6.00 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 6.00 |
| CHEMBL258817 | — | — | 1 | 5.96 |
| CHEMBL271826 | — | — | 1 | 5.82 |
| CHEMBL270951 | — | — | 1 | 5.69 |
| CHEMBL405928 | — | — | 1 | 5.67 |
| CHEMBL258816 | — | — | 2 | 5.67 |
| CHEMBL262354 | — | — | 1 | 5.54 |
| CHEMBL270920 | — | — | 1 | 5.52 |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | 5.36 |
| CHEMBL272837 | — | — | 1 | 5.30 |
| CHEMBL259031 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407954 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL260961 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL270735 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL272032 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL261179 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL261178 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL261178 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL556930 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL272253 | DEHYDRO-ALPHA-LAPACHONE | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL260744 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL407954 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL318782 | Dichlon | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL412131 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL271827 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL272225 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL106562 | 2-Methoxy-1,4-naphthoquinone | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL411532 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL260523 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL443067 | — | IC50 | = | 976.0 | nM | 6.01 |
| CHEMBL43612 | JUGLONE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL590 | MENADIONE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL258817 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL271827 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL271826 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL270951 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL405928 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL258816 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL262354 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL270920 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL258816 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL443067 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL272837 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL259031 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL52347 | 1,2-NAPHTHOQUINONE | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL240963 | LAWSONE | IC50 | = | 675000.0 | nM | - |
| CHEMBL8320 | BENZOQUINONE | Activity | - | — | - | |
| CHEMBL358225 | Cresoquinone | Activity | - | — | - | |
| CHEMBL274117 | — | Activity | - | — | - | |
| CHEMBL1550 | PHYTONADIONE | Activity | - | — | - | |
| CHEMBL13311 | CHROMONE | Activity | - | — | - |