Assay Detail
Functional
CHEMBL935531
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Cytotoxicity against human H460 cells under hypoxic condition after 2 hrs by Alamar blue staining assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.52 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 7.72 |
| CHEMBL260427 | — | — | 1 | 7.08 |
| CHEMBL404776 | — | — | 1 | 6.96 |
| CHEMBL408385 | — | — | 1 | 6.92 |
| CHEMBL261442 | — | — | 1 | 6.68 |
| CHEMBL72793 | — | — | 1 | 6.58 |
| CHEMBL403718 | — | — | 1 | 5.24 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL260427 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL404776 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL408385 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL261442 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL72793 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL403718 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 11000.0 | nM | 4.96 |