Assay Detail
Functional
CHEMBL935587
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Antimalarial activity against Plasmodium falciparum GC03
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.48 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207675 | SODIUM ARESUNATE | — | 1 | 8.96 |
| CHEMBL261818 | — | — | 1 | 8.52 |
| CHEMBL1630 | — | — | 1 | 8.35 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207675 | SODIUM ARESUNATE | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL261818 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1630 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 8.1 | nM | 8.09 |