Assay Detail
Binding
CHEMBL935617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.39 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.43 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.37 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL262628 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL262628 | — | Ki | = | 102.0 | nM | 6.99 |