Assay Detail
Functional
CHEMBL935705
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Antiviral activity against HCV 1b replicon in human Huh7/C24 cells after 72 hrs
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.16 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401825 | — | — | 1 | 8.30 |
| CHEMBL257959 | — | — | 1 | 7.80 |
| CHEMBL257750 | — | — | 1 | 7.66 |
| CHEMBL256945 | — | — | 1 | 7.52 |
| CHEMBL267934 | — | — | 1 | 7.33 |
| CHEMBL257568 | — | — | 1 | 7.27 |
| CHEMBL257960 | — | — | 1 | 7.21 |
| CHEMBL401951 | — | — | 1 | 7.16 |
| CHEMBL254756 | — | — | 1 | 6.96 |
| CHEMBL401595 | — | — | 1 | 6.89 |
| CHEMBL256946 | — | — | 1 | 6.77 |
| CHEMBL257356 | — | — | 1 | 6.50 |
| CHEMBL253534 | — | — | 1 | 6.46 |
| CHEMBL254755 | — | — | 1 | 6.43 |
| CHEMBL401931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401825 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL257959 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL257750 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL256945 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL267934 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL257568 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL257960 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL401951 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL254756 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL401595 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL256946 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL257356 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL253534 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL254755 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL401931 | — | EC50 | - | — | - |