Assay Detail
Binding
CHEMBL935755
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methyl-uronamide from mouse recombinant adenosine A1 receptor expressed in HEK293 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.02 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 8.23 |
| CHEMBL2112163 | — | — | 1 | 8.18 |
| CHEMBL2368366 | — | — | 1 | 8.17 |
| CHEMBL27376 | — | — | 1 | 8.13 |
| CHEMBL2368455 | — | — | 1 | 8.06 |
| CHEMBL175543 | — | — | 1 | 7.82 |
| CHEMBL2112157 | — | — | 1 | 7.54 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 7.46 |
| CHEMBL257573 | — | — | 1 | 7.34 |
| CHEMBL402574 | — | — | 1 | 7.34 |
| CHEMBL283057 | — | — | 1 | 7.26 |
| CHEMBL2112161 | — | — | 1 | 7.00 |
| CHEMBL2112162 | — | — | 1 | 6.96 |
| CHEMBL256312 | — | — | 1 | 6.82 |
| CHEMBL257405 | — | — | 1 | 6.80 |
| CHEMBL2368367 | — | — | 1 | 6.68 |
| CHEMBL255907 | — | — | 1 | 6.53 |
| CHEMBL257785 | — | — | 1 | 6.26 |
| CHEMBL256520 | — | — | 1 | 6.15 |
| CHEMBL402607 | — | — | 1 | 5.94 |
| CHEMBL436649 | — | — | 1 | 5.87 |
| CHEMBL258421 | — | — | 1 | 5.86 |
| CHEMBL257833 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL2112163 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL2368366 | — | Ki | = | 6.83 | nM | 8.17 |
| CHEMBL27376 | — | Ki | = | 7.32 | nM | 8.13 |
| CHEMBL2368455 | — | Ki | = | 8.79 | nM | 8.06 |
| CHEMBL175543 | — | Ki | = | 15.3 | nM | 7.82 |
| CHEMBL2112157 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL257573 | — | Ki | = | 45.4 | nM | 7.34 |
| CHEMBL402574 | — | Ki | = | 45.6 | nM | 7.34 |
| CHEMBL283057 | — | Ki | = | 55.3 | nM | 7.26 |
| CHEMBL2112161 | — | Ki | = | 98.9 | nM | 7.00 |
| CHEMBL2112162 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL256312 | — | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL257405 | — | Ki | = | 159.0 | nM | 6.80 |
| CHEMBL2368367 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL255907 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL257785 | — | Ki | = | 546.0 | nM | 6.26 |
| CHEMBL256520 | — | Ki | = | 703.0 | nM | 6.15 |
| CHEMBL402607 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL436649 | — | Ki | = | 1340.0 | nM | 5.87 |
| CHEMBL258421 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL257833 | — | Ki | = | 10500.0 | nM | 4.98 |