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Assay Detail

CHEMBL936078

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli beta-lactamase SCO1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-lactamase SCO-1 (CHEMBL1075073)
Type SINGLE PROTEIN
Organism Escherichia coli

Publication

SCO-1, a novel plasmid-mediated class A beta-lactamase with carbenicillinase characteristics from Escherichia coli.
Papagiannitsis CC, Loli A, Tzouvelekis LS, Tzelepi E, Arlet G, Miriagou V.
Antimicrob Agents Chemother (2007) 51 : 2185 -2188
PubMed 17353248 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.79 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404 TAZOBACTAM 4.0 1 8.00
CHEMBL777 CLAVULANIC ACID 4.0 1 7.16
CHEMBL403 SULBACTAM 4.0 1 5.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404 TAZOBACTAM IC50 = 10.0 nM 8.00
CHEMBL777 CLAVULANIC ACID IC50 = 70.0 nM 7.16
CHEMBL403 SULBACTAM IC50 = 6200.0 nM 5.21