Assay Detail

CHEMBL936249

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HCV 1b-N

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Evolution of resistant M414T mutants among hepatitis C virus replicon cells treated with polymerase inhibitor A-782759.

Lu L, Mo H, Pilot-Matias TJ, Molla A.
Antimicrob Agents Chemother (2007) 51 : 1889 -1896
PubMed 17371824 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	7.78	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL297884	CILUPREVIR	2.0	1	8.40
CHEMBL403145	—	—	1	7.16

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL297884	CILUPREVIR	EC50	=	4.0	nM	8.40
CHEMBL403145	—	EC50	=	70.0	nM	7.16