Assay Detail
Binding
CHEMBL936345
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Binding affinity at human CCK2 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.23 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324547 | NETAZEPIDE | 2.0 | 1 | 10.10 |
| CHEMBL205455 | — | — | 1 | 9.00 |
| CHEMBL320141 | — | — | 1 | 8.60 |
| CHEMBL147186 | — | — | 1 | 8.00 |
| CHEMBL321761 | — | — | 1 | 7.60 |
| CHEMBL317181 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324547 | NETAZEPIDE | Ki | = | 0.07943 | nM | 10.10 |
| CHEMBL205455 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL320141 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL147186 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL321761 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL317181 | — | Ki | = | 794.33 | nM | 6.10 |