Assay Detail
Binding
CHEMBL936346
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Binding affinity to human CCK1 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.77 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324547 | NETAZEPIDE | 2.0 | 1 | 7.50 |
| CHEMBL321761 | — | — | 1 | 7.30 |
| CHEMBL320141 | — | — | 1 | 7.10 |
| CHEMBL147186 | — | — | 1 | 6.90 |
| CHEMBL317181 | — | — | 1 | 6.80 |
| CHEMBL205455 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324547 | NETAZEPIDE | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL321761 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL320141 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL147186 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL317181 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL205455 | — | Ki | = | 10000.0 | nM | 5.00 |