Assay Detail
Functional
CHEMBL936348
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Agonist activity at CCK1 receptor assessed as stimulation of contraction in guinea pig gallbladder
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.57 | 7.40 |
| pKb | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147186 | — | — | 1 | 7.40 |
| CHEMBL317181 | — | — | 1 | 6.40 |
| CHEMBL321761 | — | — | 1 | 5.90 |
| CHEMBL152455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147186 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL317181 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL321761 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL152455 | — | pKb | = | 6.3 | — | - |