Assay Detail

CHEMBL936491

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Binding

Inhibition of BH3 peptide binding to human recombinant BCL-XL by fluorescence polarization assay

ChEMBL ↗

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Target

Bcl2-associated agonist of cell death (CHEMBL3817) ↗

Open DB target context

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Bcl2-associated agonist of cell death (CHEMBL3817) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bcl2-associated agonist of cell death

CHEMBL3817

Anchored from Assay target.

Protein identity Bcl2-associated agonist of cell death

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Bcl2-associated agonist of cell death (CHEMBL3817) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.

Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Bélec L, Billot X, Acoca S, Purisima E, Wiegmans A, Cluse L, Johnstone RW, Beauparlant P, Shore GC.
Proc Natl Acad Sci U S A (2007) 104 : 19512 -19517
PubMed 18040043 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.00	6.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL408194	OBATOCLAX	3.0	1	6.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL408194	OBATOCLAX	Ki	=	1000.0	nM	6.00