Assay Detail

CHEMBL936499

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Binding

Inhibition of BH3 peptide binding to human recombinant A1 by fluorescence polarization assay

ChEMBL ↗

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Target

Bcl-2-related protein A1 (CHEMBL6044) ↗

Open DB target context

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Bcl-2-related protein A1 (CHEMBL6044) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bcl-2-related protein A1

CHEMBL6044

Anchored from Assay target.

Protein identity Bcl-2-related protein A1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Bcl-2-related protein A1 (CHEMBL6044) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.

Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Bélec L, Billot X, Acoca S, Purisima E, Wiegmans A, Cluse L, Johnstone RW, Beauparlant P, Shore GC.
Proc Natl Acad Sci U S A (2007) 104 : 19512 -19517
PubMed 18040043 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.00	6.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL408194	OBATOCLAX	3.0	1	6.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL408194	OBATOCLAX	Ki	=	1000.0	nM	6.00