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Assay Detail

CHEMBL936641

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of COX2
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.
Kakuta H, Zheng X, Oda H, Harada S, Sugimoto Y, Sasaki K, Tai A.
J Med Chem (2008) 51 : 2400 -2411
PubMed 18363350 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 5.17 6.36

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL259972 MOFEZOLAC 4.0 1 6.36
CHEMBL6 INDOMETHACIN 4.0 1 4.96
CHEMBL275809 FR-122047 1 4.19
CHEMBL261520 1 -
CHEMBL261321 1 -
CHEMBL260564 1 -
CHEMBL442465 1 -
CHEMBL260566 1 -
CHEMBL261265 1 -
CHEMBL261266 1 -
CHEMBL408808 1 -
CHEMBL261485 1 -
CHEMBL406881 1 -
CHEMBL261598 1 -
CHEMBL406515 1 -
CHEMBL261815 1 -
CHEMBL279404 1 -
CHEMBL405417 1 -
CHEMBL406328 1 -
CHEMBL259539 1 -
CHEMBL25 ASPIRIN 4.0 1 -
CHEMBL260386 1 -
CHEMBL260387 1 -
CHEMBL409023 1 -
CHEMBL261550 1 -
CHEMBL405319 1 -
CHEMBL429148 1 -
CHEMBL258656 1 -
CHEMBL407577 1 -
CHEMBL264163 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL259972 MOFEZOLAC IC50 = 440.0 nM 6.36
CHEMBL6 INDOMETHACIN IC50 = 11000.0 nM 4.96
CHEMBL275809 FR-122047 IC50 = 65000.0 nM 4.19
CHEMBL261520 IC50 > 100000.0 nM -
CHEMBL261321 IC50 > 100000.0 nM -
CHEMBL260564 IC50 > 100000.0 nM -
CHEMBL442465 IC50 > 100000.0 nM -
CHEMBL260566 IC50 > 100000.0 nM -
CHEMBL261265 IC50 > 100000.0 nM -
CHEMBL261266 IC50 > 100000.0 nM -
CHEMBL408808 IC50 > 100000.0 nM -
CHEMBL261485 IC50 > 100000.0 nM -
CHEMBL406881 IC50 > 100000.0 nM -
CHEMBL261598 IC50 > 100000.0 nM -
CHEMBL406515 IC50 > 100000.0 nM -
CHEMBL261815 IC50 > 100000.0 nM -
CHEMBL279404 IC50 > 100000.0 nM -
CHEMBL405417 IC50 > 100000.0 nM -
CHEMBL406328 IC50 > 100000.0 nM -
CHEMBL259539 IC50 > 100000.0 nM -
CHEMBL25 ASPIRIN IC50 = 710000.0 nM -
CHEMBL260386 IC50 > 100000.0 nM -
CHEMBL260387 IC50 > 100000.0 nM -
CHEMBL409023 IC50 = 210000.0 nM -
CHEMBL261550 IC50 > 100000.0 nM -
CHEMBL405319 IC50 > 100000.0 nM -
CHEMBL429148 IC50 > 100000.0 nM -
CHEMBL258656 IC50 > 100000.0 nM -
CHEMBL407577 IC50 > 100000.0 nM -
CHEMBL264163 IC50 > 100000.0 nM -