Assay Detail
Binding
CHEMBL936651
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Inhibition of [14C]SPD uptake at polyamine transporter in mouse L1210 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Designing the polyamine pharmacophore: influence of N-substituents on the transport behavior of polyamine conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.78 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419870 | — | — | 1 | 7.30 |
| CHEMBL429141 | — | — | 1 | 6.85 |
| CHEMBL264968 | — | — | 1 | 6.34 |
| CHEMBL421884 | — | — | 1 | 5.75 |
| CHEMBL260932 | — | — | 1 | 5.46 |
| CHEMBL258876 | — | — | 1 | 5.37 |
| CHEMBL260931 | — | — | 1 | 5.26 |
| CHEMBL258803 | — | — | 1 | 5.09 |
| CHEMBL254003 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419870 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL429141 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL264968 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL421884 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL260932 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL258876 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL260931 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL258803 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL254003 | — | Ki | = | 24400.0 | nM | 4.61 |