Assay Detail
Binding
CHEMBL936658
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Binding affinity to CB1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.81 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 8.70 |
| CHEMBL412071 | — | — | 1 | 8.24 |
| CHEMBL412262 | IBIPINABANT | 2.0 | 1 | 8.11 |
| CHEMBL50925 | — | — | 1 | 7.15 |
| CHEMBL411481 | — | — | 1 | 6.85 |
| CHEMBL410267 | — | — | 1 | - |
| CHEMBL376700 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111 | RIMONABANT | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL412071 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL412262 | IBIPINABANT | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL50925 | — | Ki | = | 70.3 | nM | 7.15 |
| CHEMBL411481 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL410267 | — | Ki | < | 100.0 | nM | - |
| CHEMBL376700 | — | Ki | = | 0.00035 | nM | - |