Assay Detail
Binding
CHEMBL936672
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Inhibition of 100 nM Mycobacterium tuberculosis H37RV InhA
24
Total Activities
24
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Enoyl-[acyl-carrier-protein] reductase [NADH] (CHEMBL1849) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.20 | 7.32 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264416 | — | — | 1 | 7.32 |
| CHEMBL264175 | — | — | 1 | 7.26 |
| CHEMBL264434 | — | — | 1 | 7.21 |
| CHEMBL264417 | — | — | 1 | 7.05 |
| CHEMBL260399 | — | — | 1 | 6.89 |
| CHEMBL259138 | — | — | 1 | 6.80 |
| CHEMBL264415 | — | — | 1 | 6.75 |
| CHEMBL405655 | — | — | 1 | 6.63 |
| CHEMBL261355 | — | — | 1 | 6.51 |
| CHEMBL263646 | — | — | 1 | 6.24 |
| CHEMBL258932 | — | — | 1 | 6.19 |
| CHEMBL404984 | — | — | 1 | 5.96 |
| CHEMBL405653 | — | — | 1 | 5.92 |
| CHEMBL262360 | — | — | 1 | 5.89 |
| CHEMBL408149 | — | — | 1 | 5.88 |
| CHEMBL264176 | — | — | 1 | 5.81 |
| CHEMBL262343 | — | — | 1 | 5.71 |
| CHEMBL407324 | — | — | 1 | 5.63 |
| CHEMBL428967 | — | — | 1 | 5.49 |
| CHEMBL404983 | — | — | 1 | 5.25 |
| CHEMBL258931 | — | — | 1 | 5.09 |
| CHEMBL264679 | — | — | 1 | 4.94 |
| CHEMBL258933 | — | — | 1 | - |
| CHEMBL429332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264416 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL264175 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL264434 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL264417 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL260399 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL259138 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL264415 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL405655 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL261355 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL263646 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL258932 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL404984 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL405653 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL262360 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL408149 | — | IC50 | = | 1315.0 | nM | 5.88 |
| CHEMBL264176 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL262343 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL407324 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL428967 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL404983 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL258931 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL264679 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL258933 | — | Activity | - | — | - | |
| CHEMBL429332 | — | IC50 | > | 100000000.0 | nM | - |