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Assay Detail

CHEMBL936679

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Binding
Inhibition of HCV 1a NS5B RNA polymerase
ChEMBL ↗
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus subtype 1a
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR.
Bioorg Med Chem Lett (2008) 18 : 3446 -3455
PubMed 18457949 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 6.85 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL256948 — — 1 8.00
CHEMBL403642 — — 1 7.80
CHEMBL408675 — — 1 7.68
CHEMBL256949 — — 1 7.58
CHEMBL409248 — — 1 7.58
CHEMBL402234 — — 1 7.55
CHEMBL411288 — — 1 7.47
CHEMBL259995 — — 1 7.33
CHEMBL255901 — — 1 7.32
CHEMBL259781 — — 1 7.30
CHEMBL259741 — — 1 7.27
CHEMBL256918 — — 1 7.27
CHEMBL258459 — — 1 7.23
CHEMBL403189 — — 1 7.16
CHEMBL261300 — — 1 7.14
CHEMBL411407 — — 1 7.12
CHEMBL410687 — — 1 7.12
CHEMBL257408 — — 1 7.11
CHEMBL253963 — — 1 7.04
CHEMBL257409 — — 1 7.04
CHEMBL410688 — — 1 7.03
CHEMBL259349 — — 1 7.01
CHEMBL261698 — — 1 6.96
CHEMBL254163 — — 1 6.92
CHEMBL402125 — — 1 6.85
CHEMBL256323 — — 1 6.82
CHEMBL262327 — — 1 6.75
CHEMBL265190 — — 1 6.72
CHEMBL256741 — — 1 6.70
CHEMBL258236 — — 1 6.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL256948 — IC50 = 10.0 nM 8.00
CHEMBL403642 — IC50 = 16.0 nM 7.80
CHEMBL408675 — IC50 = 21.0 nM 7.68
CHEMBL256949 — IC50 = 26.0 nM 7.58
CHEMBL409248 — IC50 = 26.0 nM 7.58
CHEMBL402234 — IC50 = 28.0 nM 7.55
CHEMBL411288 — IC50 = 34.0 nM 7.47
CHEMBL259995 — IC50 = 47.0 nM 7.33
CHEMBL255901 — IC50 = 48.0 nM 7.32
CHEMBL259781 — IC50 = 50.0 nM 7.30
CHEMBL259741 — IC50 = 54.0 nM 7.27
CHEMBL256918 — IC50 = 54.0 nM 7.27
CHEMBL258459 — IC50 = 59.0 nM 7.23
CHEMBL403189 — IC50 = 70.0 nM 7.16
CHEMBL261300 — IC50 = 72.0 nM 7.14
CHEMBL411407 — IC50 = 76.0 nM 7.12
CHEMBL410687 — IC50 = 75.0 nM 7.12
CHEMBL257408 — IC50 = 77.0 nM 7.11
CHEMBL253963 — IC50 = 91.0 nM 7.04
CHEMBL257409 — IC50 = 92.0 nM 7.04
CHEMBL410688 — IC50 = 93.0 nM 7.03
CHEMBL259349 — IC50 = 97.0 nM 7.01
CHEMBL261698 — IC50 = 110.0 nM 6.96
CHEMBL254163 — IC50 = 120.0 nM 6.92
CHEMBL402125 — IC50 = 140.0 nM 6.85
CHEMBL256323 — IC50 = 150.0 nM 6.82
CHEMBL262327 — IC50 = 180.0 nM 6.75
CHEMBL265190 — IC50 = 190.0 nM 6.72
CHEMBL256741 — IC50 = 200.0 nM 6.70
CHEMBL258236 — IC50 = 210.0 nM 6.68
CHEMBL265447 — IC50 = 220.0 nM 6.66
CHEMBL260083 — IC50 = 260.0 nM 6.58
CHEMBL254164 — IC50 = 290.0 nM 6.54
CHEMBL258899 — IC50 = 300.0 nM 6.52
CHEMBL255239 — IC50 = 300.0 nM 6.52
CHEMBL399631 — IC50 = 340.0 nM 6.47
CHEMBL403641 — IC50 = 380.0 nM 6.42
CHEMBL259335 — IC50 = 400.0 nM 6.40
CHEMBL258027 — IC50 = 450.0 nM 6.35
CHEMBL401595 — IC50 = 460.0 nM 6.34
CHEMBL256324 — IC50 = 480.0 nM 6.32
CHEMBL258237 — IC50 = 490.0 nM 6.31
CHEMBL409672 — IC50 = 510.0 nM 6.29
CHEMBL260084 — IC50 = 600.0 nM 6.22
CHEMBL258028 — IC50 = 690.0 nM 6.16
CHEMBL257195 — IC50 = 1200.0 nM 5.92
CHEMBL436646 — IC50 = 1800.0 nM 5.75
CHEMBL261697 — IC50 = 2500.0 nM 5.60
CHEMBL401825 — IC50 < 25.0 nM -
CHEMBL261298 — IC50 < 25.0 nM -