Assay Detail
Binding
CHEMBL936729
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Displacement of [3H]5-HT from human 5HT2C receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.89 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407909 | — | — | 1 | 9.05 |
| CHEMBL259480 | — | — | 1 | 8.62 |
| CHEMBL406585 | — | — | 1 | 8.29 |
| CHEMBL262862 | — | — | 1 | 8.06 |
| CHEMBL405829 | — | — | 1 | 7.85 |
| CHEMBL261489 | — | — | 1 | 7.70 |
| CHEMBL406957 | — | — | 1 | 7.70 |
| CHEMBL261490 | — | — | 1 | 7.64 |
| CHEMBL429689 | — | — | 1 | 7.37 |
| CHEMBL405717 | — | — | 1 | 7.34 |
| CHEMBL407636 | — | — | 1 | 7.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407909 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL259480 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL406585 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL262862 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL405829 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL261489 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL406957 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL261490 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL429689 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL405717 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL407636 | — | Ki | = | 66.0 | nM | 7.18 |