Assay Detail
Binding
CHEMBL936730
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Displacement of [3H]5-HT from human 5HT2A receptor expressed in CHO cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259480 | — | — | 1 | 8.00 |
| CHEMBL407909 | — | — | 1 | 7.89 |
| CHEMBL406585 | — | — | 1 | 7.52 |
| CHEMBL261489 | — | — | 1 | 7.34 |
| CHEMBL405829 | — | — | 1 | 7.29 |
| CHEMBL406957 | — | — | 1 | 7.21 |
| CHEMBL405717 | — | — | 1 | 7.05 |
| CHEMBL262862 | — | — | 1 | 7.03 |
| CHEMBL261490 | — | — | 1 | 7.00 |
| CHEMBL429689 | — | — | 1 | 6.89 |
| CHEMBL407636 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259480 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL407909 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL406585 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL261489 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL405829 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL406957 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL405717 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL262862 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL261490 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL429689 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL407636 | — | Ki | = | 400.0 | nM | 6.40 |