Assay Detail
Binding
CHEMBL936779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3K
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase regulatory subunit alpha (CHEMBL2506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.22 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127907 | — | — | 1 | 8.70 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.85 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.42 |
| CHEMBL104468 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127907 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL50 | QUERCETIN | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL104468 | — | IC50 | = | 13000.0 | nM | 4.89 |