Assay Detail
Binding
CHEMBL936788
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Inhibition of Cdk2/ cyclin E
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.67 | 7.82 |
| Ki | 2 | 7.59 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298445 | — | — | 1 | 8.70 |
| CHEMBL258721 | — | — | 1 | 7.82 |
| CHEMBL261644 | — | — | 1 | 6.47 |
| CHEMBL75680 | ALOISINE A | — | 1 | 6.40 |
| CHEMBL264685 | — | — | 1 | 6.28 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.16 |
| CHEMBL541643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298445 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL258721 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL261644 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL75680 | ALOISINE A | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL264685 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL541643 | — | IC50 | >= | 3400.0 | nM | - |