Assay Detail
Binding
CHEMBL936830
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Inhibition of mouse COX2 V349I mutant 20 mins preincubated before addition of [1-14C]arachidonic acid
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.96 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260111 | — | — | 1 | 7.27 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.22 |
| CHEMBL259218 | — | — | 1 | 7.17 |
| CHEMBL76084 | — | — | 1 | 7.12 |
| CHEMBL404108 | LUMIRACOXIB | 4.0 | 1 | 6.94 |
| CHEMBL407368 | — | — | 1 | 6.92 |
| CHEMBL259842 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260111 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL259218 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL76084 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL404108 | LUMIRACOXIB | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL407368 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL259842 | — | IC50 | = | 891.0 | nM | 6.05 |