Assay Detail

CHEMBL937045

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Functional

Inhibition of FcepsilonRI-mediated degranulation in rat RBL2H3 cells

ChEMBL ↗

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Target

RBL-2H3 (CHEMBL614632) ↗

Open DB target context

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RBL-2H3 (CHEMBL614632) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target RBL-2H3

CHEMBL614632

Anchored from Assay target.

Protein identity RBL-2H3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	RBL-2H3
Confidence	1 — Organism
Curated By	Autocuration

Target

RBL-2H3 (CHEMBL614632) ↗

Type	CELL-LINE
Organism	Rattus norvegicus

Publication

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S.
Proc Natl Acad Sci U S A (2007) 104 : 20523 -20528
PubMed 18077363 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.50	6.50

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL101797	—	—	1	6.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL101797	—	EC50	=	313.0	nM	6.50