Assay Detail

CHEMBL937174

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Functional

Inhibition of HGF-mediated thymidine incorporation in human KB cells

ChEMBL ↗

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Target

KB (CHEMBL398) ↗

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Primary target KB

CHEMBL398

Anchored from Assay target.

Protein identity KB

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	KB
Confidence	1 — Organism
Curated By	Autocuration

Target

KB (CHEMBL398) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S.
Proc Natl Acad Sci U S A (2007) 104 : 20523 -20528
PubMed 18077363 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.74	8.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL258940	FALNIDAMOL	2.0	1	8.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL258940	FALNIDAMOL	IC50	=	1.82	nM	8.74