Assay Detail
Binding
CHEMBL937441
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Inhibition of human SAHH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.77 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129014 | NORARISTEROMYCIN | — | 1 | 5.96 |
| CHEMBL49935 | ARISTEROMYCIN | — | 1 | 5.31 |
| CHEMBL262063 | — | — | 1 | 4.80 |
| CHEMBL405186 | — | — | 1 | 4.33 |
| CHEMBL129469 | — | — | 1 | 4.20 |
| CHEMBL261619 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129014 | NORARISTEROMYCIN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL49935 | ARISTEROMYCIN | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL262063 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL405186 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL129469 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL261619 | — | IC50 | = | 90700.0 | nM | 4.04 |