Assay Detail
Binding
CHEMBL937442
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Inhibition of Plasmodium falciparum SAHH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.23 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405186 | — | — | 1 | 5.70 |
| CHEMBL262063 | — | — | 1 | 5.68 |
| CHEMBL129014 | NORARISTEROMYCIN | — | 1 | 5.51 |
| CHEMBL261619 | — | — | 1 | 5.35 |
| CHEMBL129469 | — | — | 1 | 4.89 |
| CHEMBL49935 | ARISTEROMYCIN | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405186 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL262063 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL129014 | NORARISTEROMYCIN | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL261619 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL129469 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL49935 | ARISTEROMYCIN | IC50 | = | 57000.0 | nM | 4.24 |