Assay Detail
Binding
CHEMBL937837
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Inhibition of chymotrypsin-like activity of human 20S proteasome
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.74 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452714 | GLYCYRRHETINIC ACID MONOISOPHTHALATE | — | 1 | 6.66 |
| CHEMBL448708 | — | — | 1 | 6.54 |
| CHEMBL449799 | GLYCYRRHETINIC ACID MONOTEREPHTHALATE | — | 1 | 6.51 |
| CHEMBL449516 | — | — | 1 | 6.46 |
| CHEMBL377754 | — | — | 1 | 6.06 |
| CHEMBL510989 | — | — | 1 | 5.98 |
| CHEMBL444697 | — | — | 1 | 5.86 |
| CHEMBL445988 | — | — | 1 | 5.75 |
| CHEMBL449992 | GLYCYRRHETINIC ACID ISOBUTYTATE | — | 1 | 5.72 |
| CHEMBL448340 | — | — | 1 | 5.71 |
| CHEMBL503862 | — | — | 1 | 5.68 |
| CHEMBL451897 | — | — | 1 | 5.64 |
| CHEMBL499915 | CARBENOXOLONE | 2.0 | 1 | 5.58 |
| CHEMBL448000 | — | — | 1 | 5.51 |
| CHEMBL318779 | — | — | 1 | 5.28 |
| CHEMBL374308 | LACTACYSTIN | — | 1 | 5.25 |
| CHEMBL505928 | — | — | 1 | 5.16 |
| CHEMBL504427 | — | — | 1 | 5.06 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 4.65 |
| CHEMBL502680 | — | — | 1 | - |
| CHEMBL450046 | GLYCYRRHETINIC ACID PROPIONATE | — | 1 | - |
| CHEMBL207413 | ACETOXOLONE | -1.0 | 1 | - |
| CHEMBL510599 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452714 | GLYCYRRHETINIC ACID MONOISOPHTHALATE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL448708 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL449799 | GLYCYRRHETINIC ACID MONOTEREPHTHALATE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL449516 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL377754 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL510989 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL444697 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL445988 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL449992 | GLYCYRRHETINIC ACID ISOBUTYTATE | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL448340 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL503862 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL451897 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL499915 | CARBENOXOLONE | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL448000 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL318779 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL374308 | LACTACYSTIN | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL505928 | — | IC50 | = | 6860.0 | nM | 5.16 |
| CHEMBL504427 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL502680 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL450046 | GLYCYRRHETINIC ACID PROPIONATE | IC50 | > | 40000.0 | nM | - |
| CHEMBL207413 | ACETOXOLONE | IC50 | > | 40000.0 | nM | - |
| CHEMBL510599 | — | IC50 | > | 40000.0 | nM | - |