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Assay Detail

CHEMBL937848

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Functional
Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 as LDH reporter activity
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Novel amodiaquine congeners as potent antimalarial agents.
Casagrande M, Basilico N, Parapini S, Romeo S, Taramelli D, Sparatore A.
Bioorg Med Chem (2008) 16 : 6813 -6823
PubMed 18562202 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.31 8.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL481934 1 8.07
CHEMBL482274 1 7.63
CHEMBL147587 ISOQUINE 1 7.62
CHEMBL524175 1 7.58
CHEMBL76 CHLOROQUINE 4.0 1 7.57
CHEMBL493248 1 7.51
CHEMBL522350 1 7.44
CHEMBL494697 1 7.37
CHEMBL493860 1 7.37
CHEMBL523509 1 7.31
CHEMBL494057 1 7.20
CHEMBL493063 1 7.16
CHEMBL492245 1 7.15
CHEMBL519110 1 7.09
CHEMBL493064 1 7.09
CHEMBL481121 1 7.04
CHEMBL493247 1 6.81
CHEMBL523159 1 6.65

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL481934 IC50 = 8.5 nM 8.07
CHEMBL482274 IC50 = 23.6 nM 7.63
CHEMBL147587 ISOQUINE IC50 = 23.7 nM 7.62
CHEMBL524175 IC50 = 26.1 nM 7.58
CHEMBL76 CHLOROQUINE IC50 = 27.2 nM 7.57
CHEMBL493248 IC50 = 30.7 nM 7.51
CHEMBL522350 IC50 = 36.5 nM 7.44
CHEMBL494697 IC50 = 42.7 nM 7.37
CHEMBL493860 IC50 = 42.9 nM 7.37
CHEMBL523509 IC50 = 48.6 nM 7.31
CHEMBL494057 IC50 = 63.5 nM 7.20
CHEMBL493063 IC50 = 69.0 nM 7.16
CHEMBL492245 IC50 = 70.7 nM 7.15
CHEMBL519110 IC50 = 81.9 nM 7.09
CHEMBL493064 IC50 = 80.7 nM 7.09
CHEMBL481121 IC50 = 90.3 nM 7.04
CHEMBL493247 IC50 = 154.1 nM 6.81
CHEMBL523159 IC50 = 222.2 nM 6.65