Assay Detail
Binding
CHEMBL938152
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Inhibition of HIV1 pNL4-3 reverse transcriptase 115F mutant by heteropolymeric DNA polymerase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.38 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258936 | — | — | 1 | 7.10 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.89 |
| CHEMBL1236349 | — | — | 1 | 5.96 |
| CHEMBL1201395 | CARBOVIR 5'-TRIPHOSPHATE, (-)- | -1.0 | 1 | 5.58 |
| CHEMBL261773 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258936 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1236349 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1201395 | CARBOVIR 5'-TRIPHOSPHATE, (-)- | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL261773 | — | IC50 | - | — | - |