Assay Detail
Binding
CHEMBL938426
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human GGPPS
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Geranylgeranyl pyrophosphate synthase (CHEMBL4769) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.75 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262616 | — | — | 1 | 7.70 |
| CHEMBL213490 | — | — | 1 | 7.22 |
| CHEMBL259026 | — | — | 1 | 7.16 |
| CHEMBL260880 | — | — | 1 | 6.96 |
| CHEMBL411274 | — | — | 1 | 6.96 |
| CHEMBL192017 | — | — | 1 | 6.64 |
| CHEMBL319144 | MINODRONIC ACID | 4.0 | 1 | 5.75 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262616 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL213490 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL259026 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL260880 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL411274 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL192017 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL319144 | MINODRONIC ACID | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4303669 | ZOLEDRONIC ACID | Ki | = | 2700.0 | nM | 5.57 |