Assay Detail
Functional
CHEMBL938515
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Antiviral activity against SARS-CoV Urbani in african green monkey Vero E6 cells assessed as cell viability after 48 hrs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.72 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490820 | — | — | 1 | 7.52 |
| CHEMBL490822 | — | — | 1 | 7.10 |
| CHEMBL496316 | — | — | 1 | 7.05 |
| CHEMBL490210 | — | — | 1 | 6.85 |
| CHEMBL497141 | — | — | 1 | 6.70 |
| CHEMBL496179 | — | — | 1 | 6.64 |
| CHEMBL510559 | — | — | 1 | 6.51 |
| CHEMBL497351 | — | — | 1 | 6.43 |
| CHEMBL497143 | — | — | 1 | 6.40 |
| CHEMBL490821 | — | — | 1 | 5.97 |
| CHEMBL490209 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490820 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL490822 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL496316 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL490210 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL497141 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL496179 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL510559 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL497351 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL497143 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL490821 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL490209 | — | IC50 | > | 100000.0 | nM | - |