Assay Detail
Binding
CHEMBL938516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SARS 3Clpro measured by rate of reaction
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1a (CHEMBL3927) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.90 | 5.16 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490820 | — | — | 1 | 5.16 |
| CHEMBL490822 | — | — | 1 | 4.92 |
| CHEMBL510559 | — | — | 1 | 4.62 |
| CHEMBL496316 | — | — | 1 | - |
| CHEMBL496179 | — | — | 1 | - |
| CHEMBL497351 | — | — | 1 | - |
| CHEMBL497143 | — | — | 1 | - |
| CHEMBL497141 | — | — | 1 | - |
| CHEMBL490821 | — | — | 1 | - |
| CHEMBL490209 | — | — | 1 | - |
| CHEMBL490210 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490820 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL490822 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL510559 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL496316 | — | EC50 | - | — | - | |
| CHEMBL496179 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL497351 | — | EC50 | - | — | - | |
| CHEMBL497143 | — | Activity | - | — | - | |
| CHEMBL497141 | — | EC50 | - | — | - | |
| CHEMBL490821 | — | Activity | - | — | - | |
| CHEMBL490209 | — | EC50 | - | — | - | |
| CHEMBL490210 | — | EC50 | - | — | - |