Assay Detail
Functional
CHEMBL938609
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Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.97 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457716 | — | — | 1 | 6.64 |
| CHEMBL458119 | — | — | 1 | 6.37 |
| CHEMBL458982 | — | — | 1 | 6.28 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 6.17 |
| CHEMBL458615 | — | — | 1 | 6.08 |
| CHEMBL457934 | — | — | 1 | 5.63 |
| CHEMBL457719 | — | — | 1 | 5.58 |
| CHEMBL457717 | — | — | 1 | 5.49 |
| CHEMBL457718 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457716 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL458119 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL458982 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL458615 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL457934 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL457719 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL457717 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL457718 | — | IC50 | = | 3540.0 | nM | 5.45 |