Assay Detail
Functional
CHEMBL938667
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Antitoxoplasma activity against wild type Toxoplasma gondii RH assessed as survival after 18 hrs by [5,6-13H]uracil incorporation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Toxoplasma gondii |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.06 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480000 | — | — | 1 | 5.34 |
| CHEMBL479811 | — | — | 1 | 5.28 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.23 |
| CHEMBL439 | SULFADIAZINE | 4.0 | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480000 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL479811 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 41200.0 | nM | 4.38 |