Assay Detail
Binding
CHEMBL938684
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Inhibition of DPP8
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.66 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471547 | — | — | 1 | 7.96 |
| CHEMBL472128 | — | — | 1 | 7.86 |
| CHEMBL471747 | — | — | 1 | 7.68 |
| CHEMBL510594 | — | — | 1 | 7.29 |
| CHEMBL471731 | — | — | 1 | 7.15 |
| CHEMBL471546 | — | — | 1 | 7.14 |
| CHEMBL397070 | — | — | 1 | 6.92 |
| CHEMBL518144 | — | — | 1 | 6.73 |
| CHEMBL481466 | — | — | 1 | 6.70 |
| CHEMBL488226 | — | — | 1 | 6.70 |
| CHEMBL488227 | — | — | 1 | 6.70 |
| CHEMBL471544 | — | — | 1 | 6.62 |
| CHEMBL461912 | — | — | 1 | 6.47 |
| CHEMBL461092 | — | — | 1 | 6.28 |
| CHEMBL453573 | — | — | 1 | 6.26 |
| CHEMBL459642 | — | — | 1 | 5.96 |
| CHEMBL469890 | — | — | 1 | 5.88 |
| CHEMBL461289 | — | — | 1 | 5.72 |
| CHEMBL455298 | — | — | 1 | 5.51 |
| CHEMBL460886 | — | — | 1 | 5.42 |
| CHEMBL501126 | — | — | 1 | 5.33 |
| CHEMBL383705 | — | — | 1 | 5.28 |
| CHEMBL461913 | — | — | 1 | 5.28 |
| CHEMBL442952 | — | — | 1 | 5.25 |
| CHEMBL460065 | — | — | 1 | 5.24 |
| CHEMBL98408 | — | — | 1 | 5.22 |
| CHEMBL503274 | — | — | 1 | 5.18 |
| CHEMBL459159 | — | — | 1 | 5.17 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 5.05 |
| CHEMBL460885 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471547 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL472128 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL471747 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL510594 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL471731 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL471546 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL397070 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL518144 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL481466 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL488226 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL488227 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL471544 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL461912 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL461092 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL453573 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL459642 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL469890 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL461289 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL455298 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL460886 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL501126 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL383705 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL461913 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL442952 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL460065 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL98408 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL503274 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL459159 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL460885 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL98008 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL461290 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL456298 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL461291 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL459643 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL511659 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL452470 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL453574 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL460887 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL459438 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL461506 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL403882 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL83418 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL511346 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL501521 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL503809 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL512705 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL446007 | — | IC50 | = | 612000.0 | nM | - |
| CHEMBL1422 | SITAGLIPTIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL98869 | — | IC50 | = | 142000.0 | nM | - |