Assay Detail
Binding
CHEMBL939118
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Inhibition of Pgp by daunorubicin accumulation assay
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.54 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | 3.0 | 2 | 7.42 |
| CHEMBL444075 | — | — | 2 | 7.06 |
| CHEMBL346292 | — | — | 2 | 6.60 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 2 | 6.36 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 2 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 38.02 | nM | 7.42 |
| CHEMBL444075 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL444075 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL346292 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL346292 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 436.52 | nM | 6.36 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 5754.4 | nM | 5.24 |