Assay Detail
Binding
CHEMBL939121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse Pgp in EMT6/AR1.0 cells after 1 hr by daunorubicin accumulation assay
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.82 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444075 | — | — | 2 | 7.30 |
| CHEMBL348475 | TARIQUIDAR | 3.0 | 2 | 7.19 |
| CHEMBL258896 | — | — | 2 | 6.59 |
| CHEMBL346292 | — | — | 2 | 6.52 |
| CHEMBL428402 | — | — | 2 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444075 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL444075 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL258896 | — | IC50 | = | 257.04 | nM | 6.59 |
| CHEMBL258896 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL346292 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL346292 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL428402 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL428402 | — | IC50 | = | 316.23 | nM | 6.50 |