Assay Detail
Binding
CHEMBL939180
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]T3 from human TRbeta receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.62 | 10.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 1 | 10.09 |
| CHEMBL263630 | — | — | 1 | 8.77 |
| CHEMBL264153 | — | — | 1 | 7.75 |
| CHEMBL263631 | — | — | 1 | 7.74 |
| CHEMBL259096 | — | — | 1 | 7.44 |
| CHEMBL260482 | — | — | 1 | 7.31 |
| CHEMBL264152 | — | — | 1 | 7.28 |
| CHEMBL258886 | — | — | 1 | 7.17 |
| CHEMBL264410 | — | — | 1 | 6.92 |
| CHEMBL407819 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | Kd | = | 0.081 | nM | 10.09 |
| CHEMBL263630 | — | Kd | = | 1.7 | nM | 8.77 |
| CHEMBL264153 | — | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL263631 | — | Kd | = | 18.4 | nM | 7.74 |
| CHEMBL259096 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL260482 | — | Kd | = | 49.0 | nM | 7.31 |
| CHEMBL264152 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL258886 | — | Kd | = | 68.0 | nM | 7.17 |
| CHEMBL264410 | — | Kd | = | 119.0 | nM | 6.92 |
| CHEMBL407819 | — | Kd | = | 2000.0 | nM | 5.70 |