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Assay Detail

CHEMBL939263

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Functional
Growth inhibition of Toxoplasma gondii tachyzoites in HFF cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Cell Type HFF
Confidence 1 — Organism
Curated By Intermediate

Target

Toxoplasma gondii (CHEMBL612888)
Type ORGANISM
Organism Toxoplasma gondii

Publication

Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Szajnman SH, García Liñares GE, Li ZH, Jiang C, Galizzi M, Bontempi EJ, Ferella M, Moreno SN, Docampo R, Rodriguez JB.
Bioorg Med Chem (2008) 16 : 3283 -3290
PubMed 18096393 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.59 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL260601 1 5.58
CHEMBL408745 1 5.20
CHEMBL259192 1 5.03
CHEMBL258541 1 4.88
CHEMBL261562 1 4.43
CHEMBL405827 1 4.37
CHEMBL406087 1 4.31
CHEMBL261432 1 4.24
CHEMBL407221 1 4.16
CHEMBL259786 1 4.15
CHEMBL258540 1 4.13
CHEMBL262598 1 -
CHEMBL261473 1 -
CHEMBL409012 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL260601 IC50 = 2600.0 nM 5.58
CHEMBL408745 IC50 = 6330.0 nM 5.20
CHEMBL259192 IC50 = 9370.0 nM 5.03
CHEMBL258541 IC50 = 13300.0 nM 4.88
CHEMBL261562 IC50 = 36940.0 nM 4.43
CHEMBL405827 IC50 = 42840.0 nM 4.37
CHEMBL406087 IC50 = 48670.0 nM 4.31
CHEMBL261432 IC50 = 57300.0 nM 4.24
CHEMBL407221 IC50 = 69810.0 nM 4.16
CHEMBL259786 IC50 = 70600.0 nM 4.15
CHEMBL258540 IC50 = 74470.0 nM 4.13
CHEMBL262598 IC50 > 100000.0 nM -
CHEMBL261473 IC50 > 50000.0 nM -
CHEMBL409012 IC50 > 50000.0 nM -