Assay Detail
Binding
CHEMBL939264
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Inhibition of Trypanosoma cruzi FPPS
16
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.34 | 7.89 |
| Ki | 1 | 6.40 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261432 | — | — | 1 | 7.89 |
| CHEMBL408745 | — | — | 1 | 7.42 |
| CHEMBL261473 | — | — | 1 | 7.24 |
| CHEMBL259786 | — | — | 1 | 6.54 |
| CHEMBL55264 | — | — | 2 | 6.40 |
| CHEMBL261562 | — | — | 1 | 6.38 |
| CHEMBL259192 | — | — | 1 | 6.31 |
| CHEMBL258540 | — | — | 1 | 6.29 |
| CHEMBL258541 | — | — | 1 | 6.12 |
| CHEMBL262598 | — | — | 1 | 6.03 |
| CHEMBL260601 | — | — | 1 | 5.99 |
| CHEMBL405827 | — | — | 1 | 5.92 |
| CHEMBL407221 | — | — | 1 | 5.85 |
| CHEMBL409012 | — | — | 1 | 5.74 |
| CHEMBL406087 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261432 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL408745 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL261473 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL259786 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL55264 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL261562 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL259192 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL258540 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL258541 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL262598 | — | IC50 | = | 944.0 | nM | 6.03 |
| CHEMBL260601 | — | IC50 | = | 1014.0 | nM | 5.99 |
| CHEMBL405827 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL407221 | — | IC50 | = | 1399.0 | nM | 5.85 |
| CHEMBL409012 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL55264 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL406087 | — | IC50 | = | 2280.0 | nM | 5.64 |