Assay Detail
Binding
CHEMBL939300
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Inhibition of Bacillus anthracis sortase A
11
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Activation of inhibitors by sortase triggers irreversible modification of the active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 10 | - | - |
| IC50 | 1 | 5.32 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407492 | — | — | 2 | 5.32 |
| CHEMBL409013 | — | — | 1 | - |
| CHEMBL234180 | — | — | 1 | - |
| CHEMBL260814 | — | — | 1 | - |
| CHEMBL260815 | — | — | 1 | - |
| CHEMBL261561 | — | — | 1 | - |
| CHEMBL258773 | — | — | 1 | - |
| CHEMBL258985 | — | — | 1 | - |
| CHEMBL233347 | — | — | 1 | - |
| CHEMBL264166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407492 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL407492 | — | Inhibition | = | 90.7 | % | - |
| CHEMBL409013 | — | Inhibition | = | 90.7 | % | - |
| CHEMBL234180 | — | Inhibition | = | 90.6 | % | - |
| CHEMBL260814 | — | Inhibition | = | 89.1 | % | - |
| CHEMBL260815 | — | Inhibition | = | 90.2 | % | - |
| CHEMBL261561 | — | Inhibition | = | 91.3 | % | - |
| CHEMBL258773 | — | Inhibition | = | 83.7 | % | - |
| CHEMBL258985 | — | Inhibition | = | 88.9 | % | - |
| CHEMBL233347 | — | Inhibition | = | 87.3 | % | - |
| CHEMBL264166 | — | Inhibition | = | 90.4 | % | - |