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Assay Detail

CHEMBL939302

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Binding
Inhibition of Bacillus anthracis sortase B
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Activation of inhibitors by sortase triggers irreversible modification of the active site.
Maresso AW, Wu R, Kern JW, Zhang R, Janik D, Missiakas DM, Duban ME, Joachimiak A, Schneewind O.
J Biol Chem (2007) 282 : 23129 -23139
PubMed 17545669 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.66 4.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL264166 1 4.85
CHEMBL407492 1 4.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL264166 IC50 = 14000.0 nM 4.85
CHEMBL407492 IC50 = 34000.0 nM 4.47