Assay Detail
Binding
CHEMBL939334
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Inhibition of Chk2
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.27 | 7.82 |
| Ki | 1 | 7.43 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179583 | — | — | 2 | 7.82 |
| CHEMBL413188 | ISOGRANULATIMIDE | — | 1 | 5.52 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179583 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL179583 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL413188 | ISOGRANULATIMIDE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 3500.0 | nM | 5.46 |