Assay Detail
Binding
CHEMBL939341
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Inhibition of VEGFR2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.96 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | — | 1 | 8.60 |
| CHEMBL13485 | SU-11652 | — | 1 | 7.57 |
| CHEMBL408565 | — | — | 1 | 7.16 |
| CHEMBL406381 | KRN-633 | 1.0 | 1 | 6.80 |
| CHEMBL101797 | — | — | 1 | 6.41 |
| CHEMBL261508 | — | — | 1 | 6.16 |
| CHEMBL260138 | ALSTERPAULLONE 2 | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL201511 | MALEIMIDE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL13485 | SU-11652 | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL408565 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL406381 | KRN-633 | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL101797 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL261508 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL260138 | ALSTERPAULLONE 2 | IC50 | = | 1000.0 | nM | 6.00 |